• Product NameAG-14361
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityAG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides.
• Target NamePARP inhibitor
• CAS No. 328543-09-5
• Calculated MW 320.39
• Formulation C19H20N4O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN(C)CC1=CC=C(C=C1)C1=NC2=CC=CC3=C2N1CCNC3=O
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair
  Receptor:PARP1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 12 mg/mL (37.45 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Calabrese CR, et al. J Natl Y Inst, 2004, 96(1), 56-67.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting