• Product NameNSC 23766
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityNSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM; does not inhibit the closely related targets, Cdc42 or RhoA.
• Target NameRho inhibitor
• CAS No. 1177865-17-6
• Calculated MW 530.96
• Formulation C24H35N7.3HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:Cl.Cl.Cl.CCN(CC)CCCC(C)NC1=NC(C)=CC(NC2=CC3=C(N)C=C(C)N=C3C=C2)=N1 |c:14,20,26,29,31,t:11,18,23|
  Pathways:Cell Cycle/Checkpoint
  Receptor:Rac GTPase
  Boling pt:
  Melting pt:
  Solubility:DMSO:100 mg/mL warmed (188.33 mM)Ethanol:<1 mg/mL (<1 mM)Water100 mg/mL warmed (188.33 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gao Y, et al. Proc Natl Acad Sci U S A, 2004, 101(20), 7618-7623.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting