• Product NameCHIR-124
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCHIR-124 is a novel and potent Chk1 inhibitor with IC50 of 0.3 nM. It shows 2,000-fold selectivity against Chk2, 500- to 5,000-fold less activity against CDK2/4 and Cdc2.
• Target NameChk inhibitor; FLT inhibitor; GSK-3 inhibitor; PDGFR inhibitor; Src inhibitor
• CAS No. 405168-58-3
• Calculated MW 419.91
• Formulation C23H22ClN5O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:ClC1=CC2=C(NC(=O)C(C3=NC4=C(N3)C=CC=C4)=C2N[C@@H]2CN3CCC2CC3)C=C1 |r,c:11,15,17,19,33,t:1,3,9|
  Pathways:PI3K/Akt/mTOR signaling; Angiogenesis; Cell Cycle/Checkpoint; Stem Cells; Tyrosine Kinase/Adaptors
  Receptor:Chk1; FLT3; GSK-3; PDGFR; Fyn
  Boling pt:
  Melting pt:
  Solubility:DMSO:7 mg/mL (16.67 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tse AN, et al, Clin Cancer Res, 2007, 13(2 Pt 1), 591-602.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting