• Product NameA-966492
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityA-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.
• Target NamePARP inhibitor
• CAS No. 934162-61-5
• Calculated MW 324.35
• Formulation C18H17FN4O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:NC(=O)C1=C2NC(=NC2=CC=C1)C1=CC=C(C=C1F)[C@@H]1CCCN1 |r,c:3,6,9,11,16,18,t:14|
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair
  Receptor:PARP1; PARP1; PARP2
  Boling pt:
  Melting pt:
  Solubility:DMSO:64 mg/mL warmed (197.31 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Penning TD, et al. J Med Chem, 2010, 53(8), 3142-53.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting