• Product NameAMG-517
• Brief DescriptionInhibitors
• Purification99.08%
• Biological ActivityAMG 517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.
• Target NameTRP/TRPV Channel antagonist
• CAS No. 659730-32-2
• Calculated MW 430.4
• Formulation C20H13F3N4O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:CC(=O)NC1=NC2=C(OC3=NC=NC(=C3)C3=CC=C(C=C3)C(F)(F)F)C=CC=C2S1
  Pathways:Membrane transporter/Ion channel
  Receptor:TRPV1
  Boling pt:
  Melting pt:
  Solubility:DMSO:86 mg/mL (199.81 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:White powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gavva NR, et al. J Pharmacol Exp Ther, 2007, 323(1), 128-137.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting