• Product NameBAF312 (Siponimod)
• Brief DescriptionInhibitors
• Purification99.13%
• Biological ActivityBAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. Phase 3.
• Target NameS1P Receptor modulator
• CAS No. 1230487-00-9
• Calculated MW 516.6
• Formulation C29H35F3N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:CCC1=C(C=CC(=C1)/C(=N/OCC2=CC(=C(C=C2)C3CCCCC3)C(F)(F)F)/C)CN4CC(C4)C(=O)O
  Pathways:GPCR/G Protein
  Receptor:S1P1; S1P2; S1P3; S1P4; S1P5
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 44 mg/mL warmed (85.17 mM); DMSO: 100 mg/mL warmed (193.57 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gergely P, et al. Br J Pharmacol, 2012, 167(5), 1035-1047.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting