• Product NameBRD73954
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityBRD73954 ia a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
• Target NameHDAC inhibitor
• CAS No. 1440209-96-0
• Calculated MW 284.31
• Formulation C16H16N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:ONC(=O)C1=CC=CC(=C1)C(=O)NCCC1=CC=CC=C1 |c:6,8,18,20,t:4,16|
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair; NF-κb
  Receptor:HDAC2; HDAC4; HDAC6; HDAC8
  Boling pt:
  Melting pt:
  Solubility:DMSO:56 mg/mL (196.96 mM)Ethanol:9 mg/mL warmed (31.65 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Olson DE, et al. J Med Chem. 2013, 56(11):4816-4820.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting