• Product NameDonepezil HCl
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityDonepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively.
• Target NameAChR inhibitor
• CAS No. 120011-70-3
• Calculated MW 416
• Formulation C24H29NO3.HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:Cl.COC1=C(OC)C=C2C(=O)C(CC3CCN(CC4=CC=CC=C4)CC3)CC2=C1 |c:2,19,21,29,t:6,17|
  Pathways:Neuroscience
  Receptor:bAChE; hAChE
  Boling pt:
  Melting pt:
  Solubility:DMSO:<1 mg/mL (<1 mM)Ethanol:<1 mg/mL (<1 mM)Water:5 mg/mL (12.01 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ogura H, et al. Methods Find Exp Clin Pharmacol. 2000, 22(8), 609-613.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting