• Product NameEW-7197
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityEW-7197 is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively. Phase 1.
• Target NameALK inhibitor
• CAS No. 1352608-82-2
• Calculated MW 399.42
• Formulation C22H18FN7
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CC1=NC(=CC=C1)C1=C(N=C(CNC2=CC=CC=C2F)N1)C1=CN2N=CN=C2C=C1 |c:3,5,16,18,27,29,32,t:1,8,10,14,24|
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK1; ALK2; ALK3; ALK4; ALK5
  Boling pt:
  Melting pt:
  Solubility:DMSO:79 mg/mL (197.78 mM)Ethanol:43 mg/mL warmed (107.65 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Jin CH, et al. J Med Chem. 2014, 57(10), 4213-4238.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting