• Product NameGaleterone
• Brief DescriptionInhibitors
• Purification99.77%
• Biological ActivityGaleterone is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. Phase 2.
• Target NameAndrogen Receptor antagonist; P450 antagonist
• CAS No. 851983-85-2
• Calculated MW 388.55
• Formulation C26H32N2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4N5C=NC6=CC=CC=C65)C)O
  Pathways:Endocrinology/Hormones; Metabolism
  Receptor:Androgen Receptor; CYP17
  Boling pt:
  Melting pt:
  Solubility:DMSO:24 mg/mL (61.76 mM)Ethanol:40 mg/mL (102.94 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Handratta VD, et al. J Med Chem, 2005, 48(8), 2972-2984.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting