• Product NameGDC-0994
• Brief DescriptionInhibitors
• Purification98.12%
• Biological ActivityGDC-0994 is a potent, orally available ERK1/2 inhibitor with IC50 of 1.1 nM and 0.3 nM, respectively. Phase 1.
• Target NameERK inhibitor
• CAS No. 1453848-26-4
• Calculated MW 440.864
• Formulation C21H18ClFN6O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1C(=CC=N1)NC2=NC=CC(=N2)C3=CC(=O)N(C=C3)[C@H](CO)C4=CC(=C(C=C4)Cl)F
  Pathways:MAPK
  Receptor:ERK1; ERK2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 87 mg/mL (197.79 mM); DMSO: 87 mg/mL (197.79 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. AACR2014. Abstract.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting