• Product NameGF109203X
• Brief DescriptionInhibitors
• Purification99.08%
• Biological ActivityGF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.
• Target NamePDGFR inhibitor; PKC inhibitor
• CAS No. 133052-90-1
• Calculated MW 412.48
• Formulation C25H24N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CN(C)CCCN1C=C(C2=CC=CC=C12)C1=C(C(=O)NC1=O)C1=CNC2=CC=CC=C12 |c:7,11,30,t:9,13,17,25,28,32|
  Pathways:Angiogenesis; Cytoskeletal Signaling
  Receptor:PDGFR; PKCα; PKCβ1; PKCβ2; PKCγ
  Boling pt:
  Melting pt:
  Solubility:DMSO:82 mg/mL (198.79 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Toullec D, et al. J Biol Chem. 1991, 266(24), 15771-15781.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting