• Product NameGolvatinib (E7050)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGolvatinib (E7050) is a dual c-Met and VEGFR-2 inhibitor with IC50 of 14 nM and 16 nM, does not inhibit bFGF-stimulated HUVEC growth (up to 1000 nM). Phase 1/2.
• Target Namec-Met/HGFR inhibitor; VEGFR inhibitor
• CAS No. 928037-13-2
• Calculated MW 633.69
• Formulation C33H37F2N7O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1CCN(CC1)C1CCN(CC1)C(=O)NC1=NC=CC(OC2=CC(F)=C(NC(=O)C3(CC3)C(=O)NC3=CC=C(F)C=C3)C=C2)=C1 |c:20,44,47,49,t:18,24,27,39,41|
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:c-Met; VEGFR2
  Boling pt:
  Melting pt:
  Solubility:DMSO:20 mg/mL (31.56 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Nakagawa T et al. Cancer Sci, 2010, 101(1), 210-215.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting