• Product NameGW5074
• Brief DescriptionInhibitors
• Purification97.30%
• Biological ActivityGW5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms is noted.
• Target NameRaf inhibitor
• CAS No. 220904-83-6
• Calculated MW 520.94
• Formulation C15H8Br2INO2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1=CC2=C(C=C1I)/C(=C/C3=CC(=C(C(=C3)Br)O)Br)/C(=O)N2
  Pathways:MAPK
  Receptor:C-Raf
  Boling pt:
  Melting pt:
  Solubility:DMSO:104 mg/mL (199.63 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chin PC, et al. J Neurochem, 2004, 90(3), 595-608.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting