• Product NameKW-2478
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityKW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM. Phase 1.
• Target NameHSP inhibitor
• CAS No. 819812-04-9
• Calculated MW 574.66
• Formulation C30H42N2O9
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCC1=C(O)C=C(O)C(C(=O)C2=CC(OC)=C(OCCN3CCOCC3)C=C2)=C1CC(=O)N(CCOC)CCOC
  Pathways:Cytoskeletal Signaling; Metabolism
  Receptor:HSP90
  Boling pt:
  Melting pt:
  Solubility:DMSO:115 mg/mL (200.11 mM)Ethanol:3 mg/mL (5.22 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Takayuki Nakashima, et al. Clin Y Res, 2010, 16(10), 2792-2802.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting