• Product NameLDC000067
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityLDC000067 is a highly selective CDK9 inhibitor with IC50 of 44 nM, 55/125/210/ >227/ >227-fold selectivity over CDK2/1/4/6/7.
• Target NameCDK inhibitor
• CAS No. 1073485-20-7
• Calculated MW 370.43
• Formulation C18H18N4O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC=CC=C1C1=NC=NC(NC2=CC(CS(N)(=O)=O)=CC=C2)=C1 |c:4,6,11,22,24,26,t:2,9,15|
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK1; CDK2; CDK4; CDK6; CDK9
  Boling pt:
  Melting pt:
  Solubility:DMSO:74 mg/mL (199.76 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Albert TK, et al. Br J Pharmacol. 2014, 171(1), 55-68.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting