• Product NameMitoxantrone
• Brief DescriptionInhibitors
• Purification97.97%
• Biological ActivityMitoxantrone is a type II topoisomerase inhibitor with IC50 of 2.0 μM, 0.42 mM for HepG2 and MCF-7/wt cells, respectively
• Target NameTopoisomerase inhibitor
• CAS No. 65271-80-9
• Calculated MW 444.48
• Formulation C22H28N4O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:OCCNCCNC1=CC=C(NCCNCCO)C2=C1C(=O)C1=C(O)C=CC(O)=C1C2=O |c:18,23,26,29,t:7,9|
  Pathways:DNA Damage/DNA Repair
  Receptor:Topo II
  Boling pt:
  Melting pt:
  Solubility:DMSO:88 mg/mL (197.98 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bellosillo B, et al. Br J Haematol, 1998, 100(1), 142-146.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting