• Product NameML130 (Nodinitib-1)
• Brief DescriptionInhibitors
• Purification99.98%
• Biological ActivityML130 (Nodinitib-1) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2.
• Target NameNOD inhibitor; TNF inhibitor
• CAS No. 799264-47-4
• Calculated MW 287.34
• Formulation C14H13N3O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:CC1=CC=C(C=C1)S(=O)(=O)N1C(N)=NC2=CC=CC=C12 |c:3,5,13,17,t:1,15,19|
  Pathways:Apoptosis; NF-κb
  Receptor:NOD1; NOD2; TNF-α
  Boling pt:
  Melting pt:
  Solubility:DMSO:57 mg/mL (198.37 mM)Ethanol:2 mg/mL (6.96 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Khan PM et al. ACS Med Chem Lett, 2011, 2(10), 780-785.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting