• Product NameNepicastat (SYN-117) HCl
• Brief DescriptionInhibitors
• Purification98.74%
• Biological ActivityNepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. Phase 2.
• Target NameHydroxylase inhibitor
• CAS No. 170151-24-3
• Calculated MW 331.81
• Formulation C14H15F2N3SHCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:C1CC2=C(C=C(C=C2C[C@H]1N3C(=CNC3=S)CN)F)F.Cl
  Pathways:Metabolism
  Receptor:Dopamine β-hydroxylase; Dopamine β-hydroxylase
  Boling pt:
  Melting pt:
  Solubility:DMSO:66 mg/mL (198.9 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Stanley WC, et al. Br J Pharmacol. 1997, 121(8), 1803-1809.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting