• Product NameNutlin-3b
• Brief DescriptionInhibitors
• Purification97.00%
• Biological ActivityNutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
• Target NameMdm2 antagonist
• CAS No. 675576-97-3
• Calculated MW 581.49
• Formulation C30H30Cl2N4O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC1=CC=C(C2=N[C@@H]([C@@H](N2C(=O)N2CCNC(=O)C2)C2=CC=C(Cl)C=C2)C2=CC=C(Cl)C=C2)C(OC(C)C)=C1 |r,c:27,35,42,t:2,4,6,22,24,30,32|
  Pathways:Apoptosis
  Receptor:Mdm2
  Boling pt:
  Melting pt:
  Solubility:DMSO:100 mg/mL (171.97 mM)Ethanol:100 mg/mL (171.97 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Vassilev LT, et al. Science, 2004, 303(5659), 844-848.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting