• Product NamePF-3758309
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPF-03758309 is a potent, ATP-competitive, pyrrolopyrazole inhibitor of PAK4 with IC50 of 1.3 nM.
• Target NamePAK inhibitor
• CAS No. 898044-15-0
• Calculated MW 490.62
• Formulation C25H30N8OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:cancer
  SMILES:CN(C)C[C@@H](NC(=O)N1CC2=C(NN=C2NC2=NC(C)=NC3=C2SC=C3)C1(C)C)C1=CC=CC=C1 |r,c:13,20,22,26,35,37,t:10,17,33|
  Pathways:Cytoskeletal Signaling
  Receptor:PAK1; PAK3; PAK4; PAK5; PAK6
  Boling pt:
  Melting pt:
  Solubility:DMSO:98 mg/mL (199.74 mM)Ethanol:98 mg/mL (199.74 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Murray BW, et al. Proc Natl Acad Sci U S A, 2010, 107(20), 9446-9451.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting