• Product NameSKI II
• Brief DescriptionInhibitors
• Purification99.93%
• Biological ActivitySKI II is a highly selective and non ATP-competitive?S1P receptor?inhibitor with?IC50?of 0.5 μM, while exhibiting no inhibitory action on other kinases including PI3K, PKCα and ERK2.
• Target NameS1P Receptor inhibitor
• CAS No. 312636-16-1
• Calculated MW 302.78
• Formulation C15H11ClN2OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:OC1=CC=C(NC2=NC(=CS2)C2=CC=C(Cl)C=C2)C=C1
  Pathways:GPCR/G Protein
  Receptor:SphK1
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 61 mg/mL (201.46 mM); DMSO: 61 mg/mL (201.46 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. French KJ, et al. Y Res, 2003, 63(18), 5962-5969.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting