• Product NameSplitomicin
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySplitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 μM, showing a higher activity in a cell-based assay.
• Target NameSirtuin inhibitor
• CAS No. 5690-3-9
• Calculated MW 198.22
• Formulation C13H10O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:O=C1CCC2=C3C=CC=CC3=CC=C2O1 |c:4,6,8,11,13|
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair
  Receptor:SIRT2p
  Boling pt:
  Melting pt:
  Solubility:DMSO:39 mg/mL (196.75 mM)Ethanol:39 mg/mL (196.75 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bedalov A, et al. Proc Natl Acad Sci U S A. 2001, 98(26), 15113-15118.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting