• Product NameSRT2104 (GSK2245840)
• Brief DescriptionInhibitors
• Purification99.45%
• Biological ActivitySRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.
• Target NameSirtuin activator
• CAS No. 1093403-33-8
• Calculated MW 516.64
• Formulation C26H24N6O2S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C(SC(=N1)C1=CC=CN=C1)C(=O)NC1=C(C=CC=C1)C1=CN2C(CN3CCOCC3)=CSC2=N1 |c:4,9,11,19,21,35,39,t:1,7,17,24|
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair
  Receptor:SIRT1
  Boling pt:
  Melting pt:
  Solubility:DMSO:16 mg/mL warmed (30.96 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Mercken EM, et al. Aging Cell. 2014, 13(5), 787-796.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting