• Product NameStaurosporine
• Brief DescriptionInhibitors
• Purification99.30%
• Biological ActivityStaurosporine is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM). Phase 3.
• Target NamePKC inhibitor; Src inhibitor
• CAS No. 62996-74-1
• Calculated MW 466.53
• Formulation C28H26N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
  Pathways:Angiogenesis; Cytoskeletal Signaling
  Receptor:PKC; PKCα; PKCγ; PKCη; c-Fgr
  Boling pt:
  Melting pt:
  Solubility:DMSO:4 mg/mL (8.57 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tamaoki T, et al. Biochem Biophys Res Commun, 1986, 135(2), 397-402.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting