• Product NameTAK-733
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityTAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. Phase 1.
• Target NameMEK inhibitor
• CAS No. 1035555-63-5
• Calculated MW 504.23
• Formulation C17H15F2IN4O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1C(=O)C(F)=C(NC2=CC=C(I)C=C2F)C2=C1N=CN(C[C@@H](O)CO)C2=O |r,c:13,17,20,t:5,8,10|
  Pathways:MAPK
  Receptor:MEK1
  Boling pt:
  Melting pt:
  Solubility:DMSO:101 mg/mL (200.3 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Qing Dong, et al. Bioorg Med Chem Lett, 2011, 21(5), 1315-1319.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting