• Product NameTolcapone
• Brief DescriptionInhibitors
• Purification99.49%
• Biological ActivityTolcapone is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with Ki of 30 nM.
• Target NameTransferase inhibitor
• CAS No. 134308-13-7
• Calculated MW 273.24
• Formulation C14H11NO5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:CC1=CC=C(C=C1)C(=O)C1=CC(=C(O)C(O)=C1)[N+]([O-])=O
  Pathways:Metabolism
  Receptor:COMT
  Boling pt:
  Melting pt:
  Solubility:DMSO:55 mg/mL (201.28 mM)Ethanol:55 mg/mL (201.28 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Zrcher G, et al. Adv Neurol, 1990, 53:497-50

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting