• Product NameTyrphostin AG 879
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityTyrphostin AG 879 potently inhibits HER2/ErbB2 with IC50 of 1 μM, 100- and 500-fold higher selective to ErbB2 than PDGFR and EGFR.
• Target NameEGFR inhibitor; HER inhibitor; PDGFR inhibitor; Trk receptor inhibitor
• CAS No. 148741-30-4
• Calculated MW 316.46
• Formulation C18H24N2OS
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC(C)(C)C1=CC(=C/C(=C(/N)\S)/C#N)C=C(C1=O)C(C)(C)C
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors; JAK/STAT signaling
  Receptor:EGFR; HER2-Neu; PDGFR; Trk
  Boling pt:
  Melting pt:
  Solubility:DMSO:36 mg/mL (113.75 mM)Ethanol:3 mg/mL (9.47 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhou Y, et al. Cancer Res, 2005, 65(13), 5848-5856.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting