• Product NameVatalanib (PTK787) 2HCl
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityVatalanib (PTK787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM, less potent against VEGFR1/Flt-1, 18-fold against VEGFR3/Flt-4. Phase 3.
• Target NamePDGFR inhibitor; VEGFR inhibitor
• CAS No. 212141-51-0
• Calculated MW 419.73
• Formulation C20H15ClN4.2HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:Cl.Cl.ClC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C3=CC=CC=C23)C=C1 |c:13,15,20,26,t:1,3,6,8,11,18,22|
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:PDGFRβ; VEGFR1/FLT1; VEGFR2/Flk1; VEGFR2/KDR; VEGFR3/FLT4
  Boling pt:
  Melting pt:
  Solubility:DMSO:85 mg/mL (202.51 mM)Ethanol:6 mg/mL (14.29 mM)Water:10 mg/mL (23.82 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wood JM, et al. Cancer Res. 2000, 60(8), 2178-2189.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting