• Product NameVU 0357121
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityVU0357121 is a novel positive allosteric modulator (PAM) of mGlu5 with EC50 of 33 nM, is inactive or very weakly antagonizing at other mGlu receptor subtypes.
• Target NameGluR agonist
• CAS No. 433967-28-3
• Calculated MW 305.32
• Formulation C17H17F2NO2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CCCCOC1=CC=C(C=C1)C(=O)NC1=C(F)C=C(F)C=C1
  Pathways:Neuroscience
  Receptor:mGluR5
  Boling pt:
  Melting pt:
  Solubility:DMSO:61 mg/mL (199.79 mM)Ethanol:21 mg/mL (68.78 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hammond AS, et al. ACS Chem Neurosci, 2010, 1(10), 702-716.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting