• Product NameVU 0361737
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityVU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors, can penetrate into CNS.
• Target NameGluR agonist
• CAS No. 1161205-04-4
• Calculated MW 262.69
• Formulation C13H11ClN2O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:COC1=CC(NC(=O)C2=NC=CC=C2)=CC=C1Cl |c:10,12,14,16,t:2,8|
  Pathways:Neuroscience
  Receptor:mGluR4 (Human); mGluR4 (Rat )
  Boling pt:
  Melting pt:
  Solubility:DMSO:53 mg/mL (201.75 mM)Ethanol:<1 mg/mL (<1 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Engers DW, et al. J Med Chem, 2009, 52(14), 4115-4118.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting