• Product NameVU 0364770
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityVU 0364770 is a positive allosteric modulator(PAM) of mGlu4 with EC50 of 1.1 μM, exhibits insignificant activity at 68 other receptors, including other mGlu subtypes.
• Target NameGluR antagonist
• CAS No. 61350-00-3
• Calculated MW 232.67
• Formulation C12H9ClN2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Nervous system
  SMILES:ClC1=CC(NC(=O)C2=NC=CC=C2)=CC=C1 |c:9,11,13,15,t:1,7|
  Pathways:Neuroscience
  Receptor:mGluR4
  Boling pt:
  Melting pt:
  Solubility:DMSO:47 mg/mL (202.0 mM)Ethanol:47 mg/mL (202.0 mM)Water:<1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Jones CK, et al. J Pharmacol Exp Ther, 2012, 340(2), 404-421.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting