• Product NameZoledronic Acid
• Brief DescriptionInhibitors
• Purification99.93%
• Biological ActivityZoledronic acid induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho.
• Target NameRho inhibitor
• CAS No. 118072-93-8
• Calculated MW 272.09
• Formulation C5H10N2O7P2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:OC(CN1C=CN=C1)(P(O)(O)=O)P(O)(O)=O
  Pathways:Cell Cycle/Checkpoint
  Receptor:Rho
  Boling pt:
  Melting pt:
  Solubility:0.1M NaOH (aq): 40 mg/ml; DMSO: 0.004 mg/mL (0.01 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Jagdev SP, et al. Br J Y, 2001, 84(8), 1126-1134.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting