• Product NameAPS-2-79
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityAPS-2-79 is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR-bound MEK.
• Target NameMAPK antagonist
• CAS No. 2002381-31-7
• Calculated MW 423.89
• Formulation C23H21N3O3HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=C4C=C(OC)C(OC)=CC4=NC=N3.[H]Cl
  Pathways:MAPK
  Receptor:KSR2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 32 mg/mL (75.49 mM) DMSO: 97 mg/mL (228.83 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Dhawan NS, et al. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature. 2016 Sep 1;537(7618):112-116.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting