• Product NameAS1842856
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityAS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form.
• Target NameFOXO1 inhibitor
• CAS No. 836620-48-5
• Calculated MW 347.38
• Formulation C18H22FN3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CCN1C=C(C(O)=O)C(=O)C2=C(N)C(F)=C(NC3CCCCC3)C=C12 |c:10,t:3,14,24|
  Pathways:Apoptosis
  Receptor:Forkhead box protein O1 (FOXO1)
  Boling pt:
  Melting pt:
  Solubility:Ethanol: <1 mg/mL DMSO: 23 mg/mL (66.2 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Nagashima T, et al. Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Mol Pharmacol. 2010 Nov;78(5):961-70.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting