• Product NameAT406 (SM-406, ARRY-334543)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAT406 (SM-406, ARRY-334543) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.
• Target NameIAP antagonist
• CAS No. 1071992-99-8
• Calculated MW 561.71
• Formulation C32H43N5O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(C1=CC=CC=C1)C1=CC=CC=C1)C(=O)CC(C)C |r,c:27,29,34,36,t:25,32|
  Pathways:Apoptosis
  Receptor:cIAP1-BIR3; cIAP2-BIR3; XIAP-BIR3
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 100 mg/mL (178.02 mM) DMSO: 100 mg/mL (178.02 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Cai Q, et al. J Med Chem, 2011, 54(8), 2714-2726.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting