• Product NameAZ6102
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityAZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.
• Target NamePPAR inhibitor
• CAS No. 1645286-75-4
• Calculated MW 428.53
• Formulation C25H28N6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C[C@H]1CN(C[C@@H](C)N1)C1=NC=C(C(C)=C1)C1=CC=C(C=C1)C1=NC2=C(C=CN2C)C(=O)N1 |r,c:11,14,19,21,28,t:9,17,24,26|
  Pathways:Metabolism
  Receptor:TNKS1; TNKS2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: <1 mg/mL DMSO: 85 mg/mL (198.35 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Johannes JW., Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology. ACS Med Chem Lett.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting