• Product NameBI-78D3
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityBI-78D3 is a competitive JNK inhibitor with IC50 of 280nM that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K.
• Target NameJNK inhibitor
• CAS No. 883065-90-5
• Calculated MW 379.37
• Formulation C13H9N5O5S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:OC1=NN=C(SC2=NC=C(S2)[N+]([O-])=O)N1C1=CC=C2OCCOC2=C1 |c:8,26,t:1,3,6,17,19|
  Pathways:MAPK
  Receptor:JNK
  Boling pt:
  Melting pt:
  Solubility:Ethanol: <1 mg/mLDMSO: 100 mg/mL (263.59 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Stebbins JL et al. Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc Natl Acad Sci U S A, 2008 Oct 28, 105(43):16809-13.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting