• Product NameCB-5083
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityCB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor with IC50 of 11 nM. Phase 1.
• Target Namep97 inhibitor
• CAS No. 1542705-92-9
• Calculated MW 413.47
• Formulation C24H23N5O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC1=CC2=C(C=CC=C2C(N)=O)N1C1=NC2=C(COCC2)C(NCC2=CC=CC=C2)=N1 |c:5,7,29,31,33,t:1,3,15,17,27|
  Pathways:Ubiquitination
  Receptor:p97
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 13 mg/mL warmed (31.44 mM) DMSO: 83 mg/mL (200.74 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Zhou HJ, et al. Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083). J Med Chem. 2015 Dec 24;58(24):9480-97.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting