• Product NameCB-839
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityCB-839 is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. Phase 1.
• Target Nametransporter inhibitor
• CAS No. 1439399-58-2
• Calculated MW 571.57
• Formulation C26H24F3N7O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:FC(F)(F)OC1=CC(CC(=O)NC2=CC=C(CCCCC3=NN=C(NC(=O)CC4=CC=CC=N4)S3)N=N2)=CC=C1 |c:30,32,37,39,41,t:5,12,14,20,22,28|
  Pathways:Metabolism
  Receptor:GLUT
  Boling pt:
  Melting pt:
  Solubility:Ethanol: <1 mg/mL (<1 mM)DMSO: 100 mg/mL (174.95 mM) warming Water: <1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Gross MI, et al. Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer. Mol Cancer Ther. 2014 Apr;13(4):890-901.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting