• Product NameDEL-22379
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityDEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of 0.5 μM.
• Target NameERK inhibitor
• CAS No. 181223-80-3
• Calculated MW 444.53
• Formulation C26H28N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:COC1=CC2=C(C=C1)NC=C2/C=C\3/C4=C(C=CC(=C4)NC(=O)CCN5CCCCC5)NC3=O
  Pathways:MAPK
  Receptor:ERK
  Boling pt:
  Melting pt:
  Solubility:Ethanol: <1 mg/mL DMSO: 89 mg/mL (200.21 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Herrero A, et al. Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes. Cancer Cell. 2015 Aug 10;28(2):170-82.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting