• Product NameFIIN-2
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityFIIN-2 is an irreversible, pan-FGFR inhibitor with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM for FGFR1/2/3/4, respectively.
• Target NameFGFR inhibitor
• CAS No. 1633044-56-0
• Calculated MW 634.73
• Formulation C35H38N8O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:COC1=CC(OC)=CC(=C1)N1CC2=CN=C(NC3=CC=C(C=C3)N3CCN(C)CC3)N=C2N(CC2=CC=C(NC(=O)C=C)C=C2)C1=O |c:6,8,20,22,33,47,t:2,13,15,18,38,40|
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:FGFR1; FGFR2; FGFR3; FGFR4
  Boling pt:
  Melting pt:
  Solubility:Ethanol: <1 mg/mLDMSO: 69 mg/mL (108.7 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Tan L, et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-4877.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting