• Product NameFLLL32
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityFLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of <5 μM.
• Target NameJAK inhibitor
• CAS No. 1226895-15-3
• Calculated MW 464.55
• Formulation C28H32O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:COC1=C(C=C(C=C1)/C=C/C(=O)C2(CCCCC2)C(=O)/C=C/C3=CC(=C(C=C3)OC)OC)OC
  Pathways:Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
  Receptor:JAK2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 25 mg/mL warmed (53.81 mM)DMSO: 92 mg/mL (198.04 mM)Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Fossey SL., et al. The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. BMC Cancer. 2011 Mar 28;11:112.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting