• Product NameUprosertib (GSK2141795)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityUprosertib (GSK2141795) is a selective, ATP-competitive, and orally bioavailable Akt inhibitor with IC50 of 180 nM, 328 nM, and 38 nM for Akt 1, 2 and 3, respectively. Phase 2.
• Target NameAkt inhibitor
• CAS No. 1047634-65-0
• Calculated MW 429.25
• Formulation C18H16Cl2F2N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CN1N=CC(Cl)=C1C1=C(Cl)OC(=C1)C(=O)N[C@H](CN)CC1=CC(F)=C(F)C=C1 |r,c:2,5,8,12,28,t:22,25|
  Pathways:Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
  Receptor:Akt1; Akt2; Akt3
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 93 mg/mL (216.65 mM) DMSO: 93 mg/mL (216.65 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Pachl F, et al. Characterization of a chemical affinity probe targeting Akt kinases. J Proteome Res. 2013 Aug 2;12(8):3792-800.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting