• Product NameGSK591
• Brief DescriptionInhibitors
• Purification99.09%
• Biological ActivityGSK591 (EPZ015866,GSK3203591) is a potent selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 11 nM.
• Target NameHistone Methyltransferase inhibitor
• CAS No. 1616391-87-7
• Calculated MW 380.48
• Formulation C22H28N4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:O[C@@H](CNC(=O)C1=CC(NC2CCC2)=NC=C1)CN1CCC2=C(C1)C=CC=C2 |r,c:14,16,23,27,29,t:6|
  Pathways:Chromatin/Epigenetic
  Receptor:PRMT5
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 76 mg/mL (199.74 mM) DMSO: 76 mg/mL (199.74 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Kenneth W. Duncan et al. ACS Med. Chem. Lett., 2016, 7 (2), pp 162-166.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting