• Product NameHalofuginone
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityHalofuginone is the competitively inhibitor of prolyl-tRNA synthetase with Ki of 18.3 nM.It could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in mammal.
• Target NameDNA/RNA Synthesis inhibitor
• CAS No. 55837-20-2
• Calculated MW 414.68
• Formulation C16H17BrClN3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:O[C@H]1CCCN[C@@H]1CC(=O)CN1C=NC2=CC(Br)=C(Cl)C=C2C1=O |r,c:13,21,t:15,18|
  Pathways:DNA Damage/DNA Repair
  Receptor:prolyl-tRNA synthetase
  Boling pt:
  Melting pt:
  Solubility:Ethanol: <1 mg/mL DMSO: 20 mg/mL (48.22 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Runlong Lin, et al. Onco Targets Ther. 2015; 8: 3549C3559.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting