• Product NameHLCL-61
• Brief DescriptionInhibitors
• Purification99.88%
• Biological ActivityHLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.
• Target NameHistone Methyltransferase inhibitor
• CAS No. 1158279-20-9
• Calculated MW 380.91
• Formulation C23H24N2OClH
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:Cl.CCN1C2=CC=CC=C2C2=C1C=CC(CNCC1=C(OC)C=CC=C1)=C2 |c:5,7,10,13,19,23,25,27,t:3|
  Pathways:Chromatin/Epigenetic
  Receptor:PRMT5
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 15 mg/mL (32.7 mM) DMSO: 55 mg/mL (119.93 mM) warming Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Tarighat SS, et al. Leukemia. 2016 Apr;30(4):789-99.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting