• Product NameIMR-1
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityIMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L.
• Target NameGamma-secretase inhibitor
• CAS No. 310456-65-6
• Calculated MW 353.41
• Formulation C15H15NO5S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CCOC(=O)COC1=C(C=C(C=C1)/C=C\2/C(=O)NC(=S)S2)OC
  Pathways:Neuroscience; Proteases/Proteasome; Stem Cells
  Receptor:Notch
  Boling pt:
  Melting pt:
  Solubility:Ethanol: <1 mg/mL DMSO: 70 mg/mL (198.07 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Astudillo L, et al. Cancer Res. 2016, 76(12):3593-603.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting