• Product NameLJH685
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityLJH685 is a potent pan-RSK inhibitor with IC50 of 6 nM, 5 nM and 4 nM for RSK1, RSK2, and RSK3, respectively.
• Target NameS6 Kinase inhibitor
• CAS No. 1627710-50-2
• Calculated MW 381.42
• Formulation C22H21F2N3O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CN1CCN(CC1)C1=CC=C(C=C1)C1=C(C=NC=C1)C1=CC(F)=C(O)C(F)=C1 |c:10,12,17,19,29,t:8,15,22,25|
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:RSK1; RSK2; RSK3
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 20 mg/mL (52.43 mM) DMSO: 76 mg/mL (199.25 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Aronchik I., et al. Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers. Mol Cancer Res. 2014 May;12(5):803-12.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting