• Product NameLY3023414
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityLY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK.
• Target NameDNA-PK inhibitor; mTOR inhibitor; PI3K inhibitor
• CAS No. 1386874-06-1
• Calculated MW 406.48
• Formulation C23H26N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CO[C@@H](C)CN1C(=O)N(C)C2=C1C1=CC(=CC=C1N=C2)C1=CC(=CN=C1)C(C)(C)O |r,c:10,15,17,20,25,27,t:13,23|
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:DNA-PK; mTOR kinase; class I PI3K isoforms
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 61 mg/mL (150.06 mM) DMSO: 47 mg/mL (115.62 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zou Y., Targeting PI3K-AKT-mTOR by LY3023414 inhibits human skin squamous cell carcinoma cell growth in vitro and in vivo. Biochem Biophys Res Commun. 2017 Aug 19;490(2):385-392.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting